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Medical hair restoration in the literal sense includes the hair loss treatment which depends upon the use of medicines. Unusual hair loss both in men and women is caused by the alterations in the androgen metabolism. Androgen is a male hormone which has a major role to play in regulation of hair growth or hair loss. The dermal papilla is the most important structure in a hair follicle which is responsible for hair-growth. It is the dermal papilla, the cell of which divides and differentiates to give rise to a new hair follicle. The dermal papilla is in direct contact with blood capillaries in the skin to derive the nutrients for the growing hair follicle. Research has shown that dermal papilla got many receptors for androgens and there are studies which have confirmed that males have more androgenic receptors in dermal papilla of their follicles as compared to females. The metabolism of androgen involves an enzyme called 5 alpha reductase which combines with the hormone androgen(testosterone) to form the DHT (Dihydro-testosterone). DHT is a natural metabolite of our body which is the root cause of hair loss. Proper nutrition is critical for the maintenance of the hair. When DHT gets into the hair follicles and roots (dermal papilla), it prevents necessary proteins, vitamins and minerals from providing nourishment needed to sustain life in the hairs of those follicles. Consequently, hair follicles are reproduced at a much slower rate. This shortens their growing stage (anagen phase) and or lengthens their resting stage (telogen phase) of the follicle. DHT also causes hair follicle to shrink and get progressively smaller and finer. This process is known as miniaturization and causes the hair to ultimately fall. DHT is responsible for 95% of hair loss. Some individuals both men and women are genetically pre-disposed to produce more DHT than the normal individuals. DHT also creates a wax-like substance around the hair roots. It is this accumulation of DHT inside the hair follicles and roots which is one of the primary causes of male and female pattern hair loss. Blocking the synthesis of DHT at molecular level forms the basis for the treatment of MPHL ( male pattern hair loss) and FPHL female pattern hair loss). There are many natural DHT blockers and a number of drugs which are used for medical hair restoration. Let us see the main drugs which are available for medical hair restoration in men and women. Minoxidil Minoxidil has the distinction of the first drug being used for promoting the hair restoration. This medical hair restoration treatment drug was used earlier as an oral antihypertensive drug, but after its hypertrichosis (excessive body hair) effects were noticed, a topical solution of the drug was tested for its hair growing potential. Minoxidil was then approved as medical hair restoration treatment drug for men by the US Food and Drug Administration (FDA) in 1988 as a 2% solution, followed by 5% solution in 1997. For women, the 2% solution was approved in 1991. Though 5% solution is not approved for women, it is used as a medical hair restoration treatment by many dermatologists worldwide. Both solutions are available without a prescription in the US. Mechanism of action Minoxidil is thought to have a direct mitogenic effect on epidermal cells, as has been observed both in vitro in vivo. Though the mechanism of its action for causing cell proliferation is not very clear, minoxidil is thought to prevent intracellular calcium entry. Calcium normally enhances epidermal growth factors to inhibit hair growth, and Minoxidil by getting converted to minoxidil sulfate acts as a potassium channel agonist and enhances potassium ion permeability to prevent calcium ions from entering into cells. Thought the exact action of minoxidil preventing the formation of DHT has not been shown but the drug has been shown to have a stabilizing effect on the hair loss. The result of the drug takes about few months time to be evident since it is the time which is necessary for restoring the normal growth cycle of hair fibers. Use of Minoxidil has approved by FDA for men (Norwood II-V) and women (Ludwig I-II ) older than 18 years. It is used as a medical hair restoration treatment either for frontal or vertex scalp thinning. It brings about an increase in density which is mostly caused by conversion of miniaturized hairs into terminal hairs rather than a stimulated de novo re-growth. The hair loss becomes stabilized after continued use of drug, which takes about a year’s time for the medical hair restoration treatment to show its complete results. Hair loss restoration treatment with 0.05% betamethasone dipropionate and 5% topical minoxidil are found to be superior to minoxidil alone. Topical minoxidil is very well tolerated and adverse effects are mainly dermatologic. The most frequent adverse effect is an irritant contact dermatitis. Though minnoxidil does not have any effect on blood pressure, it should be used with caution in patient with cardiovascular diseases. It is also contraindicated in pregnant and nursing mothers. Finasteride The drug finasteride was earlier used as treatment for prostate enlargement, under the medical name Proscar. But in 1998, it was approved by FDA for the Medical hair loss restoration in MPHL. Mechanism of Action Medical hair restoration treatments with Finasteride depends upon its specific action as an inhibitor of type II 5α-reductase, the intracellular enzyme that converts male hormone androgen into DHT (Dihydro Testosterone). Its action results in significant decrease in serum and tissue DHT levels in even in concentration as low as 0.2mg. Finnasteride is able to stabilize hair loss in 80% of patient with Vertex hair loss and in 70% of patients with frontal hair loss. Most of these patients are able to grow more hair or retain the ones they have. The peculiar thing about Propecia is that its effect is more pronounced in crown area than in the front. The hair that grow after the medical hair restoration treatments are better in texture and are thicker, more like the terminal hair. The best thing about medical hair restoration treatment with the finnasteride is that it is well tolerated and has minimal side effects. Sexual dysfunction (decreased sex drive, erectile dysfunction, and decreased semen volume) are observed in about 3.8% of cases. But these side-effects subside within few months of Medical hair restoration treatments or disappear within a week’s time as soon as the treatment is stopped. It generally requires about 6 to 12 months for the m edical hair restoration treatment to be apparent but the side effects appear earlier. So even after the medicine is stopped, there is no possibility of loosing the hair that has been gained, but the side effects are sure to disappear. Many hair restoration surgeons find Propecia (finasteride) to act as an excellent adjunct to the surgical hair restoration. There are several benefits of this kind of combination therapy. As the Medical hair restoration with Propecia brings about a hair re-growth in the crown area, it has a complementary action; it allows the surgeon to have more donor hair to be available for frontal hair transplant and design the hairline at his own will. Since finasteride has no effect in the frontal area of the scalp, it does not have any interference with the surgical hair restoration. Combination Therapy There are reports which say that use of finasteride and topical minoxidil combination therapy as a Medical hair restoration treatment is of more advantage in cases of mild to moderate MPHL. Further studies are in progress. Many hair restoration doctors have already started the use of combination therapy in order to obtain better hair growth. Anti Androgen Therapy For women with hyperandrogonism( with increased levels of androgen) who do not respond well to minoxidil, antiandrogen therapy is another option of Medical hair restoration. In UK the most commonly used anti-androgen for women is CPA (cyproterone acetate), which is used in combination with ethinyl-estradiol. However, in United States, where CPA is not available, the aldosterone antagonist spironolactone is the alternative choice of hair restoration doctors. Flutamide Medical hair restoration with flutamide has shown improvement as hair loss restoration treatment in women with hirsutism. For hyperandrogenic premenopausal women, flutamide is a better medical hair restoration agent than both the CPA or finestride. Hair loss restoration management is a structured process which depends upon many factors along with the medical hair restoration. For more details on the topic you can refer to section medical hair restoration or article on male pattern hair loss or female pattern hair loss at our site hairtransplantadvice.com. compare penis enlargement pill home penis enargement penis enhancement surgery picture penis enlargement result vimax herbal natural penis enlargement result review vig rx penis enlargement testimonials natural pnis enlargement pills

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Recently I wrote an article entitled, "Future Internet: Collaboration without loss of individuality: Example 1: Ebay". Since then it has come to my attention that like all other areas of life the comedians and jokers have invaded and put their mark on this incredible new phenomenon. I am by no means against humour as I am a firm believer in the idea that laughter is the greatest medicine of all. If humanity just learned to laugh at ourselves a little bit more instead of taking everything in life so seriously, I think we could achieve both individual and social harmony much more quickly. There are several websites on the Internet already dedicated to weird things that have been offered and even bought on www.ebay.com. A few that I've seen are found at: http://www.whowouldbuythat.com/, http://www.weird-websites.com/WeirdEbay.htm, and www.whattheheck.com/ebay/. Certain eccentric as well as just plainly silly people have tried to sell anything from their own virginity (had to be a hoax) to the now infamous 'ghost in a jar'. The 'ghost in a jar' sale was so popular that a whole slew of copycats have followed suit ranging from 'ghost droppings' to a 'ghost in a bra'. The 'What the heck' site seems to have the most comprehensive list with items being categorised into: Fan favourites, People, Body parts and fluids, Animal Kingdom, Metaphysical Stuff, Face it you're addicted to Ebay, Technology and accessories, Health and Beauty, Dirt, Water etc, Just plain evil, Gross, Weird inventions, and Stuff we've yet to categorise. One of my favourites is for the sale of Snow. Here's what the seller had to say about the product: "So far, we've got over a foot, and it's still coming down. We really don't need more than a few inches here, so we're making the rest available to the highest bidder. Due to the perishable nature of snow, and because not even 4WD vehicles are having much luck on our local roads, the winning bidder must make arrangements for pickup. This snow doesn't pack very well, so you'll have to make your own packing arrangements as well. Note that I'm only offering the excess snow from our own property. If you need it, I may be able to arrange for you to get more. I'll accept cash or money order for payment. If you clear a path from Interstate 40 to my house, I'll discount your winning bid, charging only an amount equivalent to the Ebay fee for the closing bid. Take our snow, please..." I also laughed when I saw that drug-free urine, raccoon's penis bones, the Internet (someone bid 1 billion dollars-it's real worth would be priceless), nine used toothbrushes, dirt from the US civil War, a UFO Finder, a Russian sub (a real one!) and Absolutely Nothing were on sale. Here's what the seller said about the latter: "ABSOLUTELY NOTHING for sale, zero, zilch, nada. NO RESERVE on this vastly under appreciated commodity. Why suffer the disappointment of shelling out big bucks on junk you don't want, can't afford, and don't need, when, for a small fee, you can completely bypass the disappointment! You expect nothing, and that's precisely what you will get. I'm hoping I can build up a regular clientele for absolutely nothing, because finding nothing is much easier to acquire than most of the other items I sell. And shipping costs are minimal, because, well, nothing weighs nothing. And it's very cheap for me to buy, as it costs me nothing. So forget about those Beamers, those houses in the suburbs, those electronic gadgets, those fashionable clothes that are outdated before you leave the store; THEY won't bring you happiness, NOTHING will! The ancient Chinese Sage advised us that less is more. Therefore, NOTHING is most. Here is your chance to FINALLY get exactly what you've always deserved! Bid with confidence, because I guarantee NOTHING! Aren't you weary of everyone whining that they can't find NOTHING to buy? Well, here it is, ladies and gentlemen, step right up and mail me your dollars, I have an unlimited supply of what you really need most in your life, but were never quite sure how to acquire it. You could pay hundreds, thousands, even tens of thousands of dollars for the same thing from any one of a hundred political organizations, religious groups, or federally mandated taxing organizations, and not get one single thing that I'm not providing for a nominal fee of a $1.00 bid. And don't despair if you get sniped out at the last minute this week, I'll have a fresh supply available next week as well. Item is guaranteed to be exactly as described. California residents please add 8.25% sales tax." So, with every great step forward for humanity we have our tricksters helping us along with their great powers of humour. With Ebay a new way of collaborative consumerism has entered the so-called 'first world' psyche. 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There are a number of prostate supplements on the market all promising to boost male health and prevent BPH and prostate cancer. But not all of these natural remedies have science behind them, so it's important to choose wisely when it comes to men's health supplements. By the age of fifty, over half of the male population will face a condition known as benign prostate hypertrophy, an enlargement of the gland caused by the accumulation of DHT, a derivative of testosterone. It can be caused by a variety of factors, including a lack of the mineral zinc, a vitamin B6 deficiency, fatty acid depletion, toxins, bacteria or pesticides. Any of these can contribute to the conversion of testosterone to DHT, causing the gland to swell. Supplements for prostate health can address these issues, and not only help prevent BPH but also help alleviate the pain and slow the progression of an existing prostate problem. That's why more and more men are turning to natural prostate supplements to give them a fighting chance and decrease their risk of prostate cancer. One of the most popular and well-researched prostate suppliments is saw palmetto, an herb from a tree native to the Atlantic seaboard. The active ingredient of this herb is beta sitosterol, a powerful compound that can actually interfere with the conversion of testosterone to DHT. As such it can prevent enlargement of the gland. It has also been shown to go one step further and shrink the prostate as well as relieve urinary problems associated with the condition. Red clover is another of the popular supplements for prostate health, and acts in a similar fashion to saw palmetto extract. It's a member of the pea family, and can inhibit DHT formation through its powerful antioxidant ability. In addition to the prostate herbs there are vitamins, minerals and other nutrients that can be helpful to men. As we mentioned above, a lack of zinc can exacerbate the problem, so ensuring that your body gets enough of this essential nutrient is crucial. It is also an important part of many other body processes. The B Family of vitamins can also help; in particular B6 should be present in all prostate supplements. This vitamin regulates the hormone involved in testosterone conversion to DHT. As such it is able to ensure that benign prostate hypertrophy is kept in check, and even prevented. Another nutrient making headlines is lycopene, which can be found in many popular male formulas. This is a powerful extract from tomatoes which can reduce inflammation and prevent the onset of prostate cancer. Although you can get it from eating tomatoes, a supplement can ensure lycopene content, where the fruit might be lacking by the time it hits store shelves. Before choosing any supplements for prostate health, make sure you speak with your doctor first and discuss your options. Although many prostate suppliments are available as stand alone products, you might reap more benefits from a comprehensive formula that contains herbal extracts, vitamins, minerals and other ingredients for male health. Since BPH affects so many men, it's important that we learn as much as we can about this condition. Prostate supplements just might be the answer to the problem.